Dr. Muhammad Saeed Iqbal
Forman Christian College,Lahore

Title : Hemicelluloses as Drug Delivery Materials

Hemicellulose is the second most abundant, renewable, non-toxic, and biodegradable hetero-polysaccharide after cellulose in plants consisting of different saccharide units [1]. The versatile physical and chemical properties of hemicelluloses make them a promising material for pharmaceutical and biomedicine applications [2, 3]. One of the most promising applications of hemicelluloses is their use in drug delivery systems [4 ??? 9]. Such systems can afford sustained, pulsatile and targeted drug deliveries. The objectives to be achieved from a delivery system are: i) to enhance bioavailability, ii) enhance efficacy and iii) minimize adverse effects. This talk will present an overview of the underlying principles and state of art relating to drug delivery.

Professor Dr. Mark G. Molony
University of Oxford,United Kingdom

Title : Natural products as inspiration for new chemistry in antibacterial and materials science

Natural products can provide inspiration for applied synthetic chemistry. This lecture describes how natural products have proved to be valuable starting points for the development of a completely novel class of antibacterial agents, and for the development of stable carbene precursors which have found application as surface modifying agents for a wide range of materials. The lecture will illustrate that the application of synthetic organic chemistry has an important role to play in the development of new technology which impacts on biology and materials science

Prof. Dr. Najam-ul-Haq
Bahauddin Zikria University,Multan

Title : Materials and the Functionalized Chemistry for Biomolecules Analysis in Diagnostics

The material science offers diverse range of materials in micro- and nano-sizes. The characteristics vary between the types of materials. Multiple applications are therefore designed based on unique properties. Health is the top beneficiary of materials, particularly the nanomaterials. This lecture is focused on the health side of applications which involve extensive work on complex biofluids. Any information from biofluid can be made available if the biomolecules are brought to their individual levels or at least separated on basis of their classes. These pretreatments prior to specific detections use materials in general and functionalized materials in particular. The functionalization???s bring specific functionalities onto the materials for the targeted separations of classes of biomolecules and more specifically, the signaling biomolecules representing a diseased process, helping in earlier diagnosis. The evolved strategies are designed in triangular form; material, targeted biomolecules and sample preparation protocol. The biomolecules cannot be detected from biofluids without the prior desalting of the samples. Functionalized materials play role in this regard through unprecedented combinations of hydrophilic and hydrophobic characteristics. The modern Omics Sciences are utilizing materials for meeting the modern needs of structural properties of biomolecules. The nanomaterials-based methodologies are fabricated particularly in the field of proteomics and metabolomics. The strategies are highly selective, specific and sensitive. The detection of enriched biomolecules is made with mass spectrometry to the extent of sequences. The materials employed encompass carbon-based, polymeric, cellulose and metal oxides. The nanomaterials are also fabricated to be used in sensing of signaling molecules. The designed nanomaterials and their functionalizations can pre-concentrate the targeted biomolecules from range of bio-samples like non-fat milk, egg yolk, human serum and HeLa cell extract.

Prof. Dr. Zeliha Selamoglu
Nigde Omer Halisdemir University,Turkey

Title : An Antiaging Molecule: The Cellular Energy Sensor ???NAD+???

Nicotinamide adenine dinucleotide (NAD+) has essential functions in metabolism. In metabolism, NAD+ is involved in redox reactions, carrying electrons from one reaction to another, therefore, found in two forms in cells. NAD+ is an oxidizing agent and it accepts electrons from other molecules and becomes reduced. The balance between the oxidized and reduced forms of NAD is called the NAD+/NADH ratio. This ratio is an important component of what is called the redox state of a cell, a measurement that reflects both the metabolic activities and the health of cells. NAD+ and its related derivatives are major coenzymes in various enzymatic reactions, such as oxidoreductases and dehydrogenases in living cells. NAD+ is also involved in fundamental metabolic processes including glycolysis, the citric acid cycle, and mitochondrial oxidative phosphorylation leading to energy production. NAD+ has been shown to be the key substrate for poly(ADP-ribosyl)polymerases, NAD+ glycohydrolases, and histone deacetylases known as sirtuins. These enzymes have been termed ???NAD+??? consumers, and are involved in modulation of DNA repair, maintenance of intracellular calcium homeostasis and immunological roles, and epigenetically modulated gene expression. Nowadays, the researchers focus on the metabolism of NAD+ is used by the body as area of intense researches on unravelling the secrets of our cellular ???energy sensor??? NAD+ for promoting healthy ageing. As a result, researches in the last two decades have shown that NAD+ is more than a mere regulator of metabolism, but rather may play a key role in the ageing process.